Seg-Flow®

Seg-Flow 1200

Seg-Flow® 1200

  • Economical
  • Single-use fluid path
  • Sampling for 1-2 reactors
  • 10” W x 7” H x 10” D
  • (25.4 cm x 17.8 cm x 25.0 cm)
Seg-Flow 4800

Seg-Flow® 4800

  • Single-use fluid path
  • Sampling for up to 8 reactors
  • 11”W x 10 ¼”H x 14”D
  • (27.9 cm x 26.0 cm x 35.6 cm)
Seg-Flow 80001

Seg-Flow® 8000i

  • Chemically inert fluid path
  • Sampling for up to 8 reactors
  • 11”W x 10 ¼”H x 14”D
  • (27.9 cm x 26.0 cm x 35.6 cm)
 

Automated On-Line Sampling Solutions

The Seg-Flow® Automated On-line Sampling System provides multiple bioprocess monitoring and control solutions for improving process performance. The Seg-Flow system’s patented Segmented On-line Sampling™ technology allows rapid and accurate sampling for 8 vessels or process streams and sample delivery to 4 analyzers and/or fraction collectors. Several feed control options are available with the Seg-Flow system, which can control 2 pumps per vessel. Existing off-line and at-line analytics are seamlessly integrated into a multi-functional on-line PAT tool through the Seg-Flow system’s communication interface and FlowWeb™ control software. The FlowWeb software simultaneously acquires all integrated instrument data and can export the data to any OPC-enabled SCADA for enhanced process monitoring and control.

instrument integrations

Instrument Integrations

  • Agilent® Infinity 1200 Series HPLC
  • Cedex Bio HT
  • Cedex HiRes Cell Analyzer
  • Mettler-Toledo Balances
  • Nova® BioProfile® FLEX 2, FLEX, Basic, 100, 300, & 400 analyzers
  • Vi-CELL® XR Cell Analyzer
  • YSI® 2700, 2900, 2950, & 7100 Biochemistry Analyzers

Sampling Solutions

  • Rapid and accurate sampling
  • Sample from 1-8 vessels/process streams
  • Deliver samples to 4 analyzers/fraction collectors
  • Withdraw cell-free or cell-containing samples
  • On-line monitoring of nutrients, metabolites & cell growth
  • Sample line is cleaned and/or sterilized after every sample

Feed Control Options

  • Control 2 feed pumps per vessel
  • Setpoint control, gravimetric feed control
  • Other feed algorithms can be programmed
  • Pump interfaces include: Watson-Marlow, Cole-Parmer®, MasterFlex®, SciLog® ACCU Digital, & Ivek
  • Other pump interfaces available upon request

SCADA Integrations

  • Sartorius BioPAT® MFCS
  • DASGIP DASware
  • Eppendorf BioCommand®
  • Broadley-James BioNet®
  • Emerson Delta V
  • Other devices and SCADA available upon request

Communication Interfaces

  • TCP/IP
  • Serial – RS-232
  • Analog I/O
  • OPC
 

Accessories

Sample-Mod 300

Sample-Mod 300

Online Sample Preparation & Collection

  • Delivers samples to 4 devices
  • Allows sample delivery precision
  • Enables sample dilution, including serial dilution
  • Allows reagent addition for sample preparation
  • Single-use fluid path
  • Zero dead volume syringe
Seg-Mod 202

Seg-Mod 202

  • Self-calibrating fluidic module for high cell density cultures
  • Compatible with any manufacturer or vessel design
  • Precise fluid management system for vessel sampling operations
  • Calculation of fluidic pull for accurate cell-free sampling means when viscosity increases, flowrate decreases
  • Ultrasonic sensors ensure pinpoint accuracy and proven reliability
  • Self-calibration of fluidic pull provides accurate sample withdrawal
  • Mounts easily on FISP® probes
  • Scale independent – use with laboratory, pilot or production vessels

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